Table 1.

Lung tumor penetrance and median survival in four SB screens

Screen	Genotype	Exp mice with lung tumors % (N)	Median survival of exp mice (days)	Ctrl mice with lung tumors % (N)	Median survival of ctrl mice (days)
wild-type	Rosa26-LsL-SB11 x T2/Onc x Spc-Cre	17% (53)	NA*	12 % (93)	NA*
p19	Rosa26-LsL-SB11 x T2/Onc x Spc-Cre x p19ARF−/−	6% (99)	303	8% (100)	326
p53	Rosa26-LsL-SB11 x T2/Onc x Spc-Cre x p53+/floxedR270H	22% (116)	419	15 % (87)	443
Pten	Rosa26-LsL-SB11 x T2/Onc x Spc-Cre x Ptenfloxed/floxed	29% (62)	320	6 % (94)	415

^*Median survival of wild-type mice was not determined because the majority lived longer than the endpoint of 1.5 years