Table 5.
Sensitivity and Specificity of Needle Core Findings for Source Block Findings, Stratified for Several Histopathological Severity Levels
| Density Estimate | Density Estimate | Density Estimate | Density Estimate | Density Estimate | ||
|---|---|---|---|---|---|---|
| Staining | >0 | ≥1 | ≥2 | ≥3 | ≥4 | |
| Total plaques | Sensitivity | 93 | 92 | 90 | 87 | NA |
| Thioflavin S | Specificity | 100 | 100 | 95 | 69 | NA |
| Neuritic plaques | Sensitivity | 93 | 90 | 91 | 41 | NA |
| Thioflavin S | Specificity | 100 | 97 | 78 | 98 | NA |
| Total plaques | Sensitivity | 95 | 95 | 87 | 80 | NA |
| IHC | Specificity | 100 | 100 | 93 | 88 | NA |
| Neurofibrillary change IHC | Sensitivity | 88 | 83 | 86 | 89 | NA |
| Specificity | 88 | 95 | 99 | 99 | NA | |
| Neurofibrillary tangles | Sensitivity | 91 | 92 | 86 | 62 | NA |
| Thioflavin S | Specificity | 92 | 97 | 97 | 98 | NA |
| p-synuclein | Sensitivity | 91 | 93 | 93 | 97 | 90 |
| IHC | Specificity | 95 | 97 | 95 | 95 | 97 |
| p-TDP-43 | Sensitivity | 87 | NA | NA | NA | NA |
| IHC | Specificity | 100 | NA | NA | NA | NA |
IHC, immunohistochemistry; p-synuclein, phosphorylated synuclein; p-TDP-43, phosphorylated TDP-43; NA, not applicable.