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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Mol Cancer Res. 2015 May 11;13(8):1197–1205. doi: 10.1158/1541-7786.MCR-15-0089

Figure 3. Delayed DNA repair by Nutlin in ovarian cancer cells with inactivated p53.

Figure 3

SKOV-3 (A) OVCAR-5 (B), and OVCAR-8 (C) ovarian cancer cell lines were cultured with Nutlin (10 µM) or vehicle control (DMSO). Whole cell protein lysates were evaluated by Western blot. Following 5 Gy of γ-radiation, neutral comet assays were used to measure DNA breaks. Each bar represents the average of 2–4 independent experiments with a minimum of 40 cells analyzed for each sample. A, *p=0.0073, **p=0.035; B, *p=0.0047, **p=0.01; C, *p=0.004, **p=0.0073, student’s t-test.