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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Mol Cancer Res. 2015 May 11;13(8):1197–1205. doi: 10.1158/1541-7786.MCR-15-0089

Figure 4. Nutlin inhibits DNA damage signaling in ovarian cancer cells.

Figure 4

SKOV-3 (A) OVCAR-5 (B), and OVCAR-8 (C) ovarian cancer cell lines were cultured with Nutlin (10 µM) or vehicle control (DMSO), and following γ-radiation, γH2AX foci were detected by immunofluorescence. The number of foci per cell was quantified. The mean of 2–3 independent experiments is graphed. Error bars represent SEM, and significance (*) determined using a confidence interval of 95%.