Table 1.
Maturation Onset (Days) in Control, Sham, and TBI Kits
| Developmental milestone | Control (n=15) | Sham (n=13) | TBI (n=19) |
|---|---|---|---|
| Eye opening | 11 (10, 12) | 11(10, 12) | 12 (11, 14)NS |
| Body elevation | 9 (7, 9) | 9 (8.5, 9.5) | 10 (9, 11) NS |
| Righting | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) NS |
| Normal gait | 8 (7, 9) | 8 (8, 8.5) | 9 (8, 10)** |
| Δ Cliff avoidance | 1 | 1 | Lost after TBI in 5/19 animals * |
| Head elevation | 9 (8, 9) | 9 (8.5, 9) | 10 (9, 10) # |
| Hopping | 11 (10, 12) | 10 (10, 12.5) | 14 (12, 14)*** |
| Cessation of falling | 7 (6, 7) | 7 (7, 8) | 9 (8, 9) ## |
p<0.05, **p<0.01, ***p<0.001 control and sham vs. TBI. #p<0.05, ##p<0.01, control vs. TBI.
Data were expressed as median (interquartile range). Body elevation, simultaneous fore- and hind-limb elevation; cliff avoidance, backward propulsion to avoid the edge of an elevated surface; head elevation, head elevated for more than 1 min; hopping, hopping for more than half of the duration of locomotion; cessation of falling, locomotion without falling.
Δ: there was a significant difference between the three groups for loss of the milestone for cliff avoidance (p value for this by Fisher's exact test was 0.02). The p values for other milestones were analyzed by one-way analysis of variance (non-parametric) and Bonferroni's multiple comparison test.
TBI, traumatic brain injury; NS, not significant.