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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Anesthesiology. 2015 Sep;123(3):569–581. doi: 10.1097/ALN.0000000000000769

Figure 2. Benzbromarone relaxes an established acetylcholine (Ach)-induced contraction in human airway smooth muscle.

Figure 2

Human airway smooth muscle was contracted with Ach EC50 and then treated with cumulatively increasing concentrations of benzbromarone (Benzb) (10 μM, 50 μM) or with vehicle (0.1% DMSO) at 30 minute intervals. Treatment with 10 μM and 50 μM benzbromarone resulted in significant relaxation (*p<0.05, **p<0.01, n=8 samples from 4 patients).