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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Anesthesiology. 2015 Sep;123(3):569–581. doi: 10.1097/ALN.0000000000000769

Figure 3. Benzbromarone relaxes an established leukotriene D4 (LTD4)-induced contraction in human airway smooth muscle.

Figure 3

Human airway smooth muscle was contracted with LTD4 (20nM) and then treated with cumulatively increasing concentrations of benzbromarone (Benzb) (10 μM, 50 μM, 100 μM) or vehicle (0.1% DMSO) at 30 minute intervals. Treatment with 10 μM, 50 μM and 100 μM benzbromarone resulted in significant relaxation (*p<0.05, **p<0.01, ***p<0.001, n=8 samples from 4 patients).