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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: J Hepatol. 2015 Apr 20;63(3):670–678. doi: 10.1016/j.jhep.2015.04.013

Figure 3. Gas6/Axl pathway is activated in CCl4-treated mice and Axl deficiency reduces CCl4-induced liver fibrosis.

Figure 3

WT and Axl KO mice were i.p. treated with CCl4 (twice a week) for 5 weeks. A, Gas6 and Axl levels in serum from WT mice treated with CCl4 or vehicle (corn oil). Additionally, in WT and Axl KO mice treated with CCl4 or vehicle were measured: B, Hydroxyproline levels in liver extracts. C, Representative images of liver sections after Sirius Red staining (20x). B, Sirius Red quantification of liver slides using Quantity One software in four random sections from each animal. E, Representative western blot of α-SMA, and MMP9 in liver extracts. E, ALT serum levels. *, P≤0.05, **, P≤0.01 vs. untreated WT mice, unless indicated. Student’s t test.