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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Pediatr Res. 2015 May 21;78(3):264–271. doi: 10.1038/pr.2015.100

Figure 7. Motor and Cognitive Function in TH- and N-treated HI rats.

Figure 7

Therapeutic hypothermia (TH) improves motor performance on the beam test. (A) Beam difficulty at first failure. Most rats in control (Cntrl) and moderate (-M) groups pass to level 2 (white bars); severe (-S) groups fail at (grey bars)/before (black bars) level 1. (B) Contralateral hindlimb slips (left panel) on the difficult beam are increased in rats with moderate HIE with normothermic recovery (*p < 0.05, N-M, grey bars > Cntrl, white bars); TH-M (black bars) rats are less impaired († p< 0.05, TH-M < N-M). No difference in ipsilateral (right) hindlimb slips (right panel). Object encoding and recognition is impaired by HI. (C) Cntrl (white bars) and Moderate HIE rats (TH-M, black bars; N-M, grey bars) show above-chance recognition of the novel object (‡ p< 0.05 DINOR > 0); severe HIE rats do not (** p< 0.05, severe HIE:N-S (hatched bar) and TH-S (dark grey bar) vs all other groups). (D) Object contact time for Moderate HIE rats is less than for Cntrls (white bar) during the sample phase. There is a trend for TH (black bar) to mitigate this effect. * p < 0.05, moderate HIE vs Cntrl; † p< 0.1,TH-M > N-M (grey bar).