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. 2015 Aug 19;10(8):e0135236. doi: 10.1371/journal.pone.0135236

Fig 1. HNE1/DDP cells were resistant to nedaplatin-induced cell death.

Fig 1

(A&B) HNE1 cells and HNE1/DDP cells were treated with the indicated concentrations of nedaplatin (A) or cispaltin (B) for 48 h. Cell viability was determined by MTT assay at the wavelength of 570 nm. Data are mean ± SD from five independent experiments. *p<0.05, **p<0.01 and ***p<0.0001 compared to HNE1 cells. (C) Western blot analysis for the expression of cleaved caspase 3 protein in HNE1 and HNE1/DDP cells treated with the indicated concentrations of nedaplatin for 48 h. (D) Western blot analysis for the expression of cleaved caspase 3 protein in HNE1 and HNE1/DDP cells treated with 6.0 μg/ml nedaplatin as indicated time.