Table 1.

Incidence Rates (95% CIs) and Adjusted Hazard Ratios (HRs) (95% CIs) of Abdominal Aortic Aneurysm From 1987–89 Through 2011 in Relation to Quartiles of White Blood Cell Count and Fibrinogen in 1987–89, ARIC

Biomarker		Quartile 1	Quartile 2	Quartile 3	Quartile 4	P for linear trend
WBC Count (1000 cells/mm3)	Quartile Range	≤ 4.8	4.9 – 5.8	5.9 – 7.0	≥ 7.1
	N at risk	3965	3840	3620	3894
	No. events	86	115	139	243
	Incidence rate*†	1.04 (0.84, 1.28)	1.46 (1.22, 1.76)	1.96 (1.66, 2.32)	3.40 (2.99, 3.85)
	Model 1 HR†	1	1.25 (0.95, 1.65)	1.64 (1.25, 2.14)	2.98 (2.33, 3.81)	<0.0001
	Model 2 HR‡	1	1.09 (0.82, 1.45)	1.24 (0.94, 1.64)	1.93 (1.49, 2.52)	<0.0001
Fibrinogen (mg/dL)	Quartile Range	≤ 259	260 – 294	295 – 337	≥ 338
	N at risk	3781	3837	3866	3805
	No. events	82	125	163	213
	Incidence rate*†	1.03 (0.83, 1.28)	1.60 (1.34, 1.90)	2.15 (1.84, 2.51)	3.08 (2.69, 3.52)
	Model 1 HR†	1	1.52 (1.15, 2.01)	2.22 (1.70, 2.89)	3.45 (2.67, 4.46)	<0.0001
	Model 2 HR‡	1	1.35 (1.01, 1.79)	1.83 (1.39, 2.40)	2.60 (1.99, 3.40)	<0.0001

^*Incidence rate per 1000 person-years.

^†Adjusted for age, sex, and race.

^‡Adjusted for age, sex, race-center, height, weight, smoking pack years, diabetes, systolic blood pressure, blood pressure medications, total cholesterol, high-density lipoprotein cholesterol, and lipid medications.

Due to missing data, counts of participants and AAA events shown are somewhat less than the maximum of 587 AAA events among 15,411 at risk, and are for Model 1. These vary slightly among biomarkers and were approximately 4% fewer in Model 2.