Table 2.

Incidence Rates (95% CIs) and Adjusted Hazard Ratios (HRs) (95% CIs) of Abdominal Aortic Aneurysm From 1993–95 Through 2011 in Relation to Quartiles of D-dimer in 1993–95, ARIC

Biomarker		Quartile 1	Quartile 2	Quartile 3	Quartile 4	P for linear trend
D-dimer (µg/mL)	Quartile Range	≤ 0.16	0.17 – 0.26	0.27 – 0.43	≥ 0.44
	N at risk	2882	3160	3136	3093
	No. events	52	81	117	181
	Incidence rate*†	1.13 (0.86, 1.48)	1.65 (1.33, 2.05)	2.47 (2.06, 2.96)	4.14 (3.58, 4.79)
	Model 1 HR†	1	1.46 (1.03, 2.06)	2.38 (1.71, 3.31)	4.31 (3.14, 5.92)	<0.0001
	Model 2 HR‡	1	1.45 (1.01, 2.08)	2.00 (1.42, 2.82)	3.72 (2.68, 5.16)	<0.0001

^*Incidence rate per 1000 person-years.

^†Adjusted for age, sex, and race.

^‡Adjusted for age, sex, race-center, height, weight, smoking pack years, diabetes, systolic blood pressure, blood pressure medications, total cholesterol, high-density lipoprotein cholesterol, and lipid medications.