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Endogenous glycogen depletion by hypoxia and glucose deprivation inhibits serotonin (5-HT)-induced smooth muscle contraction through exaggerated AMPK phosphorylation, which would occur via: i) diminished association of glycogen with the glycogen-binding domain (GBD) of AMPKβ subunit; and ii) ↑AMP/ATP ratio upon coordinated inhibition of ATP synthesis (by glycogen depletion) and increase in ATP consumption (by [Ca2+]i elevating agents that activate ATP-driven Ca2+ pumps).
