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. 2015 Jul 7;290(34):20723–20733. doi: 10.1074/jbc.R115.656884

FIGURE 2.

FIGURE 2.

Structures of the Tet enzymes. a, schematic representation of human Tet1 (hTet1) C-terminal catalytic domain and NgTet1. b, structure of NgTet1-DNA complex (Protein Data Bank (PDB) 4LT5). The NgTet1 protein folds in a three-layered jelly-roll structure. c, sequence alignment of human TET1, TET2, and TET3 (NP_085128.2, NP_001120680.1, and NP_001274420.1), mouse Tet1, Tet2, and Tet3 (NP_081660.1, NP_001035490.2, and NP_898961.2), honey bee (A. mellifera) AmTet (GB52555 in BeeBase OSGv3.2), and NgTet1 (XP_002667965.1). d, structure of human TET2-DNA complex (PDB 4NM6). The secondary structure elements are labeled according to NgTet1 structure (panel b). Note the large insertion in human TET2 between strands 8 and 9 (magenta), which is indicated by a magenta arrow in panel c.