FIGURE 7.

Reduced levels of phospho-eIF2α and increased levels of phospho-IP₃R1 in Cnga3^−/−/Nrl^−/−/Gucy2e^−/− retinas. Shown are representative images of the Western blot detection of phospho-eIF2α and phospho-IP₃R1 in retinas of Cnga3^−/−/Nrl^−/−/Gucy2e^−/−, Cnga3^−/−/Nrl^−/−, and Nrl^−/− mice at P30 (A) and the corresponding densitometric analysis (B). The relative expression levels in Cnga3^−/−/Nrl^−/− and Cnga3^−/−/Nrl^−/−/Gucy2e^−/−mice were normalized to the values in Nrl^−/− mice. Data are represented as means ± S.E. of measurements from 3 to 4 assays using retinas prepared from 4 to 5 mice. Unpaired Student's t test was used for determination of the significance of differences between the drug-treated and vehicle-treated mice (**, p < 0.01).