Figure 6.

Increased glucocorticoids are associated with increased protein degradation and decreased strength. (A) Mouse grip strength (N) assessed at baseline, 4, 8 and 12 weeks of dexamethasone treatment. Muscle atrogene (B) and proteasomal transcript expression changes in gastrocnemius muscles from mice following 1 week of dexamethasone treatment. (C) Proteasomal mRNA levels from subcutaneous adipose tissue of mice treated with dexamethasone for 12 weeks. Proteasomal (D) and protein catabolism (E) transcript expression changes in subcutaneous adipose tissue from Cushing's disease and control subjects. (F) Heatmap of differentially expressed ribosomal transcripts in Cushing's disease and control subjects. * indicates q<0.05.