Table 2.

Perioperative chemotherapy in gastric carcinoma: Randomized trials

Studies	Country	Years	Randomization arms	Surgery	Protocol	Patients (n)	Overall survival	P value	Disease free survival	P value
MRC MAGIC trial[17]	United Kingdom	2006	Chemotherapy and surgery	42.5% D2 surgery	ECF chemotherapy	250	36.3% at 5 yr1	0.009	34.8% at 5 yr1	< 0.001
			Surgery alone			253	23% at 5 yr		24.9% at 5 yr
ACCORD07/FFCD 9703 trial[18]	France	2011	Chemotherapy and surgery	D2 recommended	5FU-CDDP chemotherapy	113	38% at 5 yr1	0.02	34% at 5 yr1	0.003
			Surgery alone			111	24% at 5 yr		19% at 5 yr

¹Statistically significant result. ECF: Epirubicin, cisplatin, and 5-fluorouracil; 5FU: 5-fluorouracil; RT: Radiotherapy; CDDP: Cisplatin.