Table 5.

Ongoing phase-III randomized trials

Study	Country	No. registration	Standard arm	Experimental arm	Patients (n)
Neoadjuvant chemoradiotherapy
EORTC 22114 - 40111 TOP GEAR study	Europe	NCT01924819	ECC/ECF preoperative CT	ECC/ECF preoperative CT and RTCT preoperative	752
Perioperative chemotherapy
MAGIC-B/ST03 study	United Kingdom	NCT00450203	ECC perioperative CT	ECC + bevacizumab perioperative CT	1100
PRODIGY trial	South Korea	NCT01515748	S-1 adjuvant CT	Neoadjuvant DOS CT and S-1 postoperative CT	640
Adjuvant chemotherapy
ARTIST II Trial	South Korea	NCT01761461	S-1 adjuvant CT (arm 1)	SOX adjuvant CT (arm 2), S-1 and RT adjuvant (arm 3)	1000
Adjuvant chemoradiotherapy
CRITICS Trial	The Netherlands	NCT00407186	ECC perioperative CT	ECC preoperative CT and RTCT postoperative	788

CT: Chemotherapy; RTCT: Radiochemotherapy; ECC: Epirubicin, cisplatin and capecitabine; ECF: Epirubicin, cisplatin, and fluorouracil; DOS: Docetaxel, oxaliplatin, and S-1; SOX: S-1 and oxaliplatin.