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. 2012 Nov 30;2012:bcr2012006687. doi: 10.1136/bcr-2012-006687

List of QT prolonging drugs

Antiarrhythmics Class 1: dihydroquinidine, disopyramide, encainide, flecainide, mexiletine, procainamide, propafenone and quinidine
Class 3: amiodarone, azimilide, bretylium, dofetilide, dronedarone, d-sotalol, ersentilide, ibutilide, nifekalant, sematilide and sotalol
Anti-anginals/vasodilators Bepridil, lidoflazine, prenylamine, ranolazine, terodiline and vardenafil
Anti-hypertensives Indapamide, isradipine, moexipril/hydrochlorthiazide and nicardipine
Antihistamines Astemizole, azelastine, diphenhydramine, ebastine, hydroxyzine and terfenadine
Serotonin agonists and antagonists Cisapride, dolasetron, granisetron, ketanserin and ondansetron
Antimicrobials Macrolide antibiotics: azithromycin, clarithromycin, erythromycin, roxithromycin, spiramycin and telithromycin
Quinolone antibiotics: ciprofloxacin, gatifloxacin, gemifloxacin, grepafloxacin, levofloxacin, moxifloxacin, ofloxacin and sparfloxacin
Antifungals: cotrimoxazole, fluconazole (caution with itraconazole), ketoconazole and voriconazole
Others: pentamidine and trimethoprim sulfa (bactrim)
Antiviral: foscarnet (HIV)
Antimalarials amantidine, chloroquine, halofantrine and quinine.
Psychiatric drugs Tricyclic antidepressants: amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline and trimipramine.
Phenothiazines: chlorpromazine, fluphenazine, prochlorperazine, thioridazine and trifluoperazine.
Others: atomoxetine, citalopram and clozapine, droperidol, fluoxetine, haloperidol, levomethadyl, lithium, maprotiline, mesoridazine, methadone, paroxetine, pericycline, pimozide, quetiapine, risperidone, sertindole, sertraline, trazodone, venlafaxine, zimeldine and ziprasidone.
Anticonvulsant Felbamate and fosphenytoin (prodrug of phenytoin).
Anti-migraine Naratriptan, sumatriptan and zolmitriptan
Anti-cancer Arsenic trioxide, geldanamycin, sunitib, tacrolimus and tamoxifen
Stimulant drugs Some cold remedies contain these drugs, so it is important always to check the label. Adrenaline (epinephrine), amphetamine, cocaine, dexmethylphenidate, dobutamine, dopamine, ephedrine, fenfluramine, isoprenaline (isoproterenol), levalbuterol, metaproterenol, methylphenidate, midodrine and norepinephrine (noradrenaline), phentermine, phenylephrine, phenylpropanolamine, pseudoephidrine, ritodrine, salbutamol (albuterol), salmeterol, sibutramine and terbutaline.
Others Alfuzosin, chloral hydrate, clobutinol, domperidone, galantamine, octreotide, organophosphates, perflutren lipid microspheres, probucol, solifenacin, tizanidine, tolterodine and vasopressin.