Table 2.

Prognostic features of transformation

	Confirmed transformation				Confirmed/suspected transformation
	HR	95% CI		χ2 P	HR	95% CI		χ2 P
		Lower	Upper			Lower	Upper
Extranodal sites				.096				.015
≤1	Ref				Ref
>1	1.37	0.95	1.99	.096	1.39	1.07	1.81	.015
Nodal sites				.588				.167
<5	Ref				Ref
≥5	1.10	0.78	1.55	.588	1.18	0.93	1.50	.167
Grade				.175				.502
I/II	Ref				Ref
III	0.94	0.60	1.49	.801	1.02	0.75	1.38	.911
Unknown/missing	1.52	0.96	2.43	.077	1.23	0.87	1.72	.242
ECOG PS				.117				<.001
0-1	Ref				Ref
2+	1.74	0.79	3.85	.173	2.12	1.27	3.55	.004
Not done/missing	1.35	0.97	1.88	.079	1.62	1.30	2.03	<.001
Hb				.274				.507
≥12 g/dL	Ref				Ref
<12 g/dL	1.32	0.91	1.93	.147	1.17	0.89	1.52	.258
Not done/missing	0.84	0.43	1.68	.626	0.97	0.63	1.50	.901
LDH				.002				.003
Normal	Ref				Ref
>ULN	2.03	1.35	3.06	.001	1.57	1.17	2.10	.003
Not done/missing	1.55	1.04	2.30	.031	1.38	1.05	1.80	.020
Stage				.025				.216
I/II	Ref				Ref
III/IV	1.65	1.06	2.55	.025	1.19	0.90	1.58	.216
B Symptoms				.035				.014
No	Ref				Ref
Yes	1.45	1.03	2.06	.035	1.35	1.06	1.72	.014
Age				.043				.087
<60	Ref				Ref
60-69	1.32	0.92	1.89	.134	1.13	0.88	1.47	.343
70-79	1.37	0.90	2.07	.141	1.41	1.06	1.88	.017
80+	0.39	0.14	1.07	.068	1.41	0.93	2.13	.104

Statistical analyses were performed using multivariable Cox regression adjusted for induction treatment.

Bold indicates significant findings, P < .05.

Ref, reference.