Skip to main content
. 2015 Aug 21;5:13390. doi: 10.1038/srep13390

Table 2. Top 10 up-regulated genes in PANC-1 cells treated by metformin and aspirin.

Gene ID Fold Change P-value Function
Metformin
 GRB7 6.48 1.41E-11 integrin signaling pathway, cell migration
 GUCA1B 5.49 2.86E-18 activates photoreceptor guanylate cyclases
 SGK2 4.48 4.41E-12 membrane transporters, cell growth, survival and proliferation
 PPP1R32 4.19 7.49E-10 unknown
 WISP2 3.33 1.11E-11 Downstream of WNT1 signaling pathway
 JAK3 3.18 4.17E-11 Stat3 pathway
 TCP11L2 3.01 3.54E-11 unknown
 AMT 3.00 4.49E-18 glycine cleavage
 NT5M 2.93 7.16E-10 Dephosphorylation
 HES7 2.93 7.44E-09 transcriptional repressor
Combination
 NGFR 47.48 1.69E-122 cell survival and differentiation
 NPTX1 20.17 1.80E-46 activates photoreceptor guanylate cyclases
 C7orf57 14.50 8.02E-41 unknown
 MRPL23AS1 12.39 4.49E-36 unknown
 UNC5B 11.20 2.37E-51 guidance of nerves/blood vessels, induce apoptosis
 DUSP15 8.91 2.66E-60 oligodendrocyte differentiation
 HES7 8.30 1.80E-33 transcriptional repressor
 MTURN 7.74 8.44E-24 early neuronal development
 SLC20A1 6.72 9.85E-36 cellular metabolism, signal transduction, and nucleic acid and lipid synthesis, extracellular matrix and cartilage calcification as well as in vascular calcification
 GPCPD1 6.42 6.24E-49 unknown