Figure 1. Comparative analyses of wild-type (WT) and Padi4 knock out (KO) mice of recombinant human Glucose-6-phosphate isomerase (rhGPI)-induced arthritis (GIA).

(A) The incidence of GIA. (B) The mean severity of GIA graded by previously reported methods. (WT n = 11, Padi4 KO n = 13) (C,D) Representative arthritic joint sections and mean histological scores were graded by previously reported methods 14 days after the immunization. ¶: inflammatory cell infiltration, §: cartilage destruction, ^†: bone erosion. Gray bars; WT, open bars; Padi4 KO. (E,F) The numbers of splenocytes and inguinal lymph node cells were counted 0, 7, and 14 days after the immunization. Pre-immunized (WT n = 3, Padi4 KO n = 3), 7 days after the immunization (WT n = 9, Padi4 KO n = 9), 14 days after the immunization (WT n = 14, Padi4 KO n = 16). *p < 0.05.