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. 2015 Jun 30;4(7):386–395. doi: 10.1002/psp4.49

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© 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Observed and predicted survival vs. time (days). (a) Observed (Kaplan-Meier), median predicted (blue line) with associated 95% confidence interval (blue area). (b) Observed (Kaplan-Meier) and model predictions (median and 95% prediction interval) stratified below and above the 50^th percentile for covariates (ECOG, time to PSA nadir [days], K_G [days⁻¹], PSA₀ [ng/ml]) in the final covariate survival, or stratified for different ECOG scores. C: Model predictions for different values of the covariates in the final survival model.