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. 2015 Jun 18;4(7):415–425. doi: 10.1002/psp4.51

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© 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Overview of IDEA. Treatment and control DTPs derived from MCF-7 cell lines were downloaded from CMap and combined to construct a DTP. DTPs were then compared against GEPs (GEP) of each patient from the breast cancer dataset of interest to generate a DRS. This resulted in a DRS profile for each drug. Each DRS profile was then used as the covariate(s) in Cox proportional hazards models. All drugs with DRS profiles that were significantly associated with patient survival were considered potential therapeutic candidates.