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. 2015 Jun 18;4(7):415–425. doi: 10.1002/psp4.51

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© 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Examples of drug candidates belonging to different pharmacological classes. (a) Kaplan-Meier curves of patients with DRS >0 and DRS <0 for etoposide. (b) Kaplan-Meier curves of patients with DRS >0 and DRS <0 for methotrexate. (c) Kaplan-Meier curves of patients with DRS >0 and DRS <0 for levonorgestrel. (d) Kaplan-Meier curves of patients with DRS >0 and DRS <0 for wortmannin. (e) Kaplan-Meier curves of patients with DRS >0 and DRS <0 for LY-294002. (f) Kaplan-Meier curves of patients with DRS >0 and DRS <0 for sirolimus.