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. 2015 Aug 21;3:51. doi: 10.3389/fcell.2015.00051

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Copyright © 2015 Komarova, Safranek, Gopalakrishnan, Ou, McKee, Murshed, Rauch and Zuhr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of parameters affecting nucleator production and removal on the mineralization outcome. (A–C) The effect of decreasing 3-fold (A) or increasing 3-fold (B) the number of nucleators per crosslinked collagen (k₂). (C) Comparison of the mineralization lag time and degree in conditions affecting k₂ to healthy mineralization. (D–F) The effect of decreasing 3-fold (D) or increasing 3-fold (E) the rate of use of nucleators by mineralized bone (r₂). (F) Comparison of the mineralization lag time and degree in conditions affecting r₂ to healthy mineralization. The same color scheme is used as in Figure 2.