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. 2015 Aug 21;3:51. doi: 10.3389/fcell.2015.00051

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Copyright © 2015 Komarova, Safranek, Gopalakrishnan, Ou, McKee, Murshed, Rauch and Zuhr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of parameters affecting collagen maturation on the mineralization outcome. (A–C) The effect of decreasing 3-fold (A) or increasing 3-fold (B) the amount of naïve collagen deposited by osteoblasts at time = 0 (x₁(0)). (C) Comparison of the mineralization lag time and degree in conditions affecting x₁(0) to healthy mineralization. (D–F) The effect of decreasing 3-fold (D) or increasing 3-fold (E) the rate of collagen maturation (k₁). (F) Comparison of the mineralization lag and degree in conditions affecting k₁ to healthy mineralization. The same color scheme is used as in Figure 2.