Figure 2. mGluR group I agonist inhibits the HPA axis response to restraint.
Rats were injected in the PVN with the group I metabotropic glutamate receptor agonist DHPG. A) Time course of ACTH secretion in response to restraint. B) Area under the curve (AUC) of ACTH secretion in response to restraint. C) Time course of corticosterone (CORT) secretion in response to restraint. D) AUC of corticosterone secretion in response to restraint. * indicates p < 0.05 vs vehicle. n = 8 (vehicle) and 9 (DHPG).