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. Author manuscript; available in PMC: 2016 Oct 15.
Published in final edited form as: Physiol Behav. 2015 Feb 19;150:2–7. doi: 10.1016/j.physbeh.2015.02.027

Figure 3. Group I mGluR antagonist treatment elevates the HPA axis response to restraint in a manner that is reversed by dexamethasone treatment.

Figure 3

Rats were injected in the PVN with the group I metabotropic glutamate receptor antagonist hexyl-HIBO and/or dexamethasone (Dex), then subjected to 30 minutes of restraint. A) Time course of ACTH secretion in response to restraint. B) Area under the curve (AUC) of ACTH secretion. C) Time course of corticosterone (CORT) secretion in response to restraint. D) AUC of corticosterone secretion in C. * indicates p < 0.05 vs. vehicle, and † indicates p < 0.05 vs dexamethasone in A and vs HIBO in B. n = 8 (vehicle), 10 (hexyl-HIBO), 7 (dexamethasone), and 8 (dexamethasone/hexyl-HIBO).