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. Author manuscript; available in PMC: 2016 Oct 15.
Published in final edited form as: Physiol Behav. 2015 Feb 19;150:2–7. doi: 10.1016/j.physbeh.2015.02.027

Figure 4. Inhibition of HPA axis response to stress by DHPG is not blocked by AM-251 treatment.

Figure 4

Rats were injected with the cannabinoid CB1 receptor antagonist AM-251 and/or DHPG into the PVN, then subjected to 30 minutes of restraint. A) ACTH time course in response to restraint. B) Area under the curve (AUC) of ACTH secretion. C) Corticosterone (CORT) time course in response to restraint. D) AUC of corticosterone secretion. * indicates p < 0.05 compared to vehicle treated animals. n = 10 (vehicle and DHPG) and 9 (AM-251 and DHPG/AM-251).