(A) 14-3-3 FKO mice (N = 34) have increased distance traveled compared with their WT littermates (N = 22) in 30 min open field testing. (B) Compared with WT (N = 19), the 14-3-3 FKO mice (N = 29) have a reduction in their alternation percentage in Y-maze testing. (C) 14-3-3 FKO mice (N = 30) have decreased PPI percentage compared with WT mice (N = 23). (D) For sociability testing, WT (N = 7) mice spend more time in the chamber containing an unfamiliar mouse, but this preference is not observed in the 14-3-3 FKO mice (N = 11). (E) In subsequent social recognition testing, WT mice spend more time in the chamber with an unfamiliar mouse compared to the familiar mouse. However, the 14-3-3 FKO mice show no preference for any of the chambers. Data are presented as mean ± S.E.M. with statistical significance denoted as: ns, not significant; *p < 0.05; **p < 0.01; ***p < 0.001, two tailed t-test (open field), one-way ANOVA (Y-maze, PPI, social interaction).