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. Author manuscript; available in PMC: 2015 Aug 21.
Published in final edited form as: Nat Med. 2010 Jun;16(6):635–636. doi: 10.1038/nm0610-635

Figure 1.

Figure 1

Basophil activation by autoreactive IgE. Peripheral blood basophils are activated by IgE-containing immune complexes (IgE-IC) to upregulate CD62L that allows them to migrate into lymphoid organs. Upregulation of MHC class II (MHC-II) confers antigen-presenting properties, and upregulation of IL-4 promulgates a TH2 (IL-4–producing) T cell phenotype. IL-4, together with increased basophil cell surface expression of BAFF and increased production of IL-6 from multiple cell types (including basophils), enhances autoantibody class switching to IgG1 that can deposit in the kidneys and IgE that further perpetuates basophil activation. TACI, transmembrane activator and calcium modulator ligand interactor.