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. Author manuscript; available in PMC: 2015 Aug 21.
Published in final edited form as: Nat Rev Microbiol. 2013 Nov 6;11(12):863–875. doi: 10.1038/nrmicro3135

Fig. 3. Establishment of the KSHV epigenome.

Fig. 3

(A) Primary infection of KSHV results in combination of both lytic and latent transcription. (B) Latency is stabilized by a CTCFI-cohesin loop between immediate early promoter region (ORF50–ORF45–46–47) and latency control region (LANA-vCyc-vFLIP). RBP-jK functions as a scaffold for activation by Rta (encoded by ORF50) during lytic and for repression by LANA during latency.