Table 2.
Clinical and biochemical parameters at baseline and at the end of the study
| Baseline | 12 weeks | 24 weeks | P1 n=25 | P2 n=24 | P3 n=24 | |
|---|---|---|---|---|---|---|
| HbA1c (%) | 7.43±0.61 | 6.78±0.74 | 6.82±0.73 | 0.005* | 0.008* | 0.057 |
| FPG (mmol/L) | 7.35±0.85 | 6.53±0.76 | 6.58±1.13 | 0.037* | 0.041* | 0.12 |
| FINS (µU/mL) | 7.74±4.38 | 8.12±4.12 | 9.04±4.08 | 0.545 | 0.890 | 0.890 |
| HOMA-% B | 48.66±21.10 | 56.43±26.32 | 64.88±34.44 | 0.656 | 0.481 | 0.481 |
| HOMA-IR | 1.29±0.72 | 1.38±0.59 | 1.47±0.66 | 0.872 | 0.673 | 0.958 |
| TC (mmol/L) | 4.55±0.78 | 4.78±0.82 | 4.47±0.48 | 0.812 | 0.465 | 0.873 |
| TG (mmol/L) | 1.78±0.79 | 2.03±0.67 | 1.98±0.78 | 0.954 | 0.115 | 0.665 |
| HDL-C (mmol/L) | 1.16±0.24 | 1.17±0.28 | 1.18±0.29 | 0.253 | 0.381 | 0.918 |
| LDL-C (mmol/L) | 2.79±0.58 | 2.95±0.72 | 2.72±0.41 | 0.330 | 0.901 | 0.845 |
| Cr (µmol/L) | 56.74±11.20 | 57.58±15.46 | 56.44±9.75 | 0.232 | 0.203 | 0.270 |
| UA (µmol/L) | 321.83±8.56 | 312.00±116.01 | 305.11±80.03 | 0.375 | 0.547 | 0.123 |
| ALT (U/L) | 21.30±4.06 | 22.08±4.40 | 22.33±4.61 | 0.950 | 0.069 | 0.869 |
| AST (U/L) | 20.09±5.48 | 21.92±5.42 | 21.33±4.97 | 0.403 | 0.064 | 0.509 |
| ALP (U/L) | 75.17±23.54 | 72.83±27.30 | 77.22±22.93 | 0.825 | 0.634 | 0.236 |
| r-GT (U/L) | 31.74±15.72 | 31.00±18.99 | 30.33±16.29 | 1.00 | 0.662 | 0.478 |
Notes: Data presented as mean ± standard deviation or as a ratio.
P-value <0.05.
Abbreviations: FPG, fasting plasma glucose; FINS, fasting serum insulin; Cr, creatinine; UA, uric acid; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; r-GT, r-glutamyl transferase; HOMA-% B, homeostasis model assessment of steady-state beta cell function; HOMA-IR, homeostasis model assessment of insulin resistance; P1, P-values for changes in variables between baseline and follow-up at 12 weeks; P2, P-values for changes in variables between baseline and follow-up at 24 weeks; P3, P-values for changes in variables between follow-up at 12 weeks and 24 weeks; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TG, triglycerides; TC, total cholesterol; HbA1c, glycosylated hemoglobin.