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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Immunol Rev. 2015 Sep;267(1):30–55. doi: 10.1111/imr.12327

Fig. 9. High variability of Cγ connecting pieces both within and across species.

Fig. 9

(A) Differences in length and features of the connecting piece/hinge of TCRγ chains in multiple species. Vγ and Cγ domains are shown in blue, with plasma membrane in orange. Examples are roughly organized from shortest to longest connecting pieces, with ranges of amino acid lengths and exon usage displayed beneath each gene name. Presence of cysteine resides marked with C. (*) Indicates allelic difference in human Cγ2 of either 2 or 3 exons. (B) Cartoon showing hypothetical regions of interaction between the TCRγ connecting piece and CD3.