TABLE III.
Tensor scale- and VTA-based trabecular bone measures: comparisons of SSRI-treated patients and matched IBDS controls.
| SSRI-treated patients (N = 12) | IBDS controls (N = 36)a | |||
|---|---|---|---|---|
| (i)-inner ROI (o)-outer ROIb | mean ± SD | mean ± SD | difference SSRI-control (%)c | Effect size (in SD units) |
| PWTS (o) | 1092 ± 272 | 1245 ± 184 | −12.5c* | 0.69 |
| PWTS (i) | 790 ± 134 | 851 ± 127 | −6.20 | 0.43 |
| PRRTS (o) | 3.46 ± 0.68 | 3.50 ± 0.48 | −0.44 | 0.05 |
| PRRTS (i) | 2.74 ± 0.66 | 2.83 ± 0.55 | −1.68 | 0.14 |
| tBMDTS (o) | 422.3 ± 49.8 | 435.0 ± 17.3 | −2.94 | 0.27 |
| tBMDTS (i) | 395.2 ± 41.6 | 414.6 ± 21.3 | −4.31 | 0.37 |
| PWVTA (o) | 918 ± 184 | 992 ± 124 | −7.23 | 0.49 |
| PWVTA (i) | 714 ± 120 | 743 ± 102 | −3.16 | 0.25 |
| PRRVTA (o) | 3.50 ± 0.47 | 3.58 ± 0.28 | −2.00 | 0.18 |
| PRRVTA (i) | 3.04 ± 0.33 | 3.08 ± 0.27 | −1.00 | 0.13 |
| SMI (o) | 1.50 ± 0.62 | 1.45 ± 0.50 | 0.80 | −0.10 |
| SMI (i) | 2.24 ± 0.31 | 2.23 ± 0.27 | 0.81 | −0.03 |
| Hip aBMD (DXA) | 1.02 ± 0.16 | 1.08 ± 0.11 | −5.04 | 0.44 |
a
A total of 36 controls from the Iowa Bone Development Study, 1 to 4 controls per SSRI patient (subgroup), mean values from subgroups were used as paired values for comparisons with matched SSRI patients. Values in this column are the mean of the control subgroup means.
b
Inner ROI (i) corresponds to the inner region of trabecular bone (60% from the outer edge), outer ROI (o) corresponds to the outer region of trabecular bone (30% to 60% from the outer edge).
c
*p-value < 0.05 from paired t-test (results were verified using nonparametric Wilcoxon matched pairs signed rank test).