Table IV.

SPINK1 SNPs association with Gleason score (GS) in prostate cancer cases.

Model	rs10035432
	Genotype	* Low GS	* High GS	** OR (95% CI)	***p-Value
Co-dominant	G/G	50 (65.8%)	42 (60.9%)	1	0.48
	A/G	18 (23.7%)	22 (31.9%)	0.69 (0.33–1.45)
	A/A	8 (10.5%)	5 (7.2%)	1.34 (0.41–4.42)
Dominant	G/G	50 (65.8%)	42 (60.9%)	1	0.54
	A/G-A/A	26 (34.2%)	27 (39.1%)	0.81 (0.41–1.59)
Recessive	G/G-A/G	68 (89.5%)	64 (92.8%)	1	0.49
	A/A	8 (10.5%)	5 (7.2%)	1.51 (0.47–4.84)
Over-dominant	G/G-A/A	58 (76.3%)	47 (68.1%)	1	0.27
	A/G	18 (23.7%)	22 (31.9%)	0.66 (0.32–1.38)
Log-additive	---	---	---	0.96 (0.58–1.58)	0.88

Model	rs11748222
	Genotype	* Low GS	* High GS	** OR (95% CI)	***p-Value
Co-dominant	T/T	67 (80.7%)	66 (84.6%)	1	0.54
	C/T	11 (13.2%)	10 (12.8%)	1.08 (0.43–2.72)
	C/C	5 (6%)	2 (2.6%)	2.46 (0.46–13.14)
Dominant	T/T	67 (80.7%)	66 (84.6%)	1	0.51
	C/T-C/C	16 (19.3%)	12 (15.4%)	1.31 (0.58–2.99)
Recessive	T/T-C/T	78 (94%)	76 (97.4%)	1	0.27
	C/C	5 (6%)	2 (2.6%)	2.44 (0.46–12.94)
Over-dominant	T/T-C/C	72 (86.8%)	68 (87.2%)	1	0.94
	C/T	11 (13.2%)	10 (12.8%)	1.04 (0.41–2.60)
Log-additive	---	---	---	1.34 (0.72–2.50)	0.36

Model	rs1432982
	Genotype	* Low GS	* High GS	** OR (95% CI)	***p-Value
Co-dominant	A/A	50 (60.2%)	50 (67.6%)	1	0.16
	A/G	21 (25.3%)	20 (27%)	1.05 (0.51–2.17)
	G/G	12 (14.5%)	4 (5.4%)	3.00 (0.91–9.94)
Dominant	A/A	50 (60.2%)	50 (67.6%)	1	0.34
	A/G-G/G	33 (39.8%)	24 (32.4%)	1.37 (0.71–2.65)
Recessive	A/A-A/G	71 (85.5%)	70 (94.6%)	1	0.05
	G/G	12 (14.5%)	4 (5.4%)	2.96 (0.91–9.61)
Over-dominant	A/A-G/G	62 (74.7%)	54 (73%)	1	0.81
	A/G	21 (25.3%)	20 (27%)	0.91 (0.45–1.87)
Log-additive	---	---	---	1.45 (0.90–2.34)	0.13

^*Low and high GS were defined as less advanced “if a case’s GS is <7” and more advanced “if their GS is >7”.

^**OR (95% CI): odd ratio and 95% confidential interval of SNP response to PCa when adjusted by age.

^***p-Value, adjusted p-value by age.