Table V.

Associations between SPINK1 SNPs and benign prostatic hyperplasia (BPH) risk.

Model	Rs10035432
	Genotype	Controls	BPH	* OR (95% CI)	**p-Value
Co-dominant	G/G	165 (58.1%)	30 (44.1%)	1	0.02
	A/G	106 (37.3%)	31 (45.6%)	0.52 (0.29–0.93)
	A/A	13 (4.6%)	7 (10.3%)	0.32 (0.11–0.90)
Dominant	G/G	165 (58.1%)	30 (44.1%)	1	0.01
	A/G-A/A	119 (41.9%)	38 (55.9%)	0.48 (0.28–0.84)
Recessive	G/G-A/G	271 (95.4%)	61 (89.7%)	1	0.11
	A/A	13 (4.6%)	7 (10.3%)	0.43 (0.16–1.16)
Over-dominant	G/G-A/A	178 (62.7%)	37 (54.4%)	1	0.07
	A/G	106 (37.3%)	31 (45.6%)	0.60 (0.34–1.05)
Log-additive	---	---	---	0.55 (0.35–0.84)	0.007

Model	rs11748222
	Genotype	Controls	BPH	* OR (95% CI)	**p-Value
Co-dominant	T/T	221 (81%)	72 (84.7%)	1	0.28
	C/T	42 (15.4%)	8 (9.4%)	1.60 (0.71–3.63)
	C/C	10 (3.7%)	5 (5.9%)	0.56 (0.18–1.76)
Dominant	T/T	221 (81%)	72 (84.7%)	1	0.6
	C/T-C/C	52 (19.1%)	13 (15.3%)	1.20 (0.61–2.37)
Recessive	T/T-C/T	263 (96.3%)	80 (94.1%)	1	0.28
	C/C	10 (3.7%)	5 (5.9%)	0.52 (0.17–1.65)
Over-dominant	T/T-C/C	231 (84.6%)	77 (90.6%)	1	0.21
	C/T	42 (15.4%)	8 (9.4%)	1.65 (0.73–3.74)
Log-additive	---	---	---	0.99 (0.60–1.64)	0.97

Model	rs1432982
	Genotype	Controls	BPH	* OR (95% CI)	**p-Value
Co-dominant	A/A	175 (60.5%)	58 (69.9%)	1	0.44
	A/G	98 (33.9%)	22 (26.5%)	1.38 (0.78–2.42)
	G/G	16 (5.5%)	3 (3.6%)	1.62 (0.45–5.89)
Dominant	A/A	175 (60.5%)	58 (69.9%)	1	0.21
	A/G-G/G	114 (39.5%)	25 (30.1%)	1.41 (0.82–2.41)
Recessive	A/A-A/G	273 (94.5%)	80 (96.4%)	1	0.55
	G/G	16 (5.5%)	3 (3.6%)	1.46 (0.41–5.27)
Over-dominant	A/A-G/G	191 (66.1%)	61 (73.5%)	1	0.31
	A/G	98 (33.9%)	22 (26.5%)	1.33 (0.76–2.33)
Log-additive	---	---	---	1.33 (0.85–2.10)	0.21

SNPStats was used to construct the haplotypes.

^*OR (95% CI): odd ratio and 95% confidential interval of SNP response to BPH when adjusted by age and WAA.

^**p-Value, adjusted p-value by age and WAA.