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. Author manuscript; available in PMC: 2015 Aug 22.
Published in final edited form as: Nat Genet. 2015 Jan 19;47(3):226–234. doi: 10.1038/ng.3189

Figure 1.

Figure 1

Manhattan plot showing the significance of SNP association in the GWAS. Each point represents 1 of the 18,322 SNPs with MAF > 0.01 in a set of 1,063 samples, colored according to chromosome. The x axis represents genomic location, and the y axis represents the P value for the SNP's association calculated using a linear mixed model (Online Methods). SNPs with P ≤ 1 × 10−7 after Bonferroni correction (n = 24; above the horizontal red line) are represented by diamond symbols. The nine loci containing these SNPs are identified in the plot and listed in Table 2. Polymorphisms with association P ≤ 1 × 10−5 (n = 24) are shown in a larger size between the horizontal orange and red lines and are listed in supplementary table 2.