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. Author manuscript; available in PMC: 2016 Jul 6.
Published in final edited form as: Chembiochem. 2015 May 15;16(10):1443–1447. doi: 10.1002/cbic.201500177

Scheme 2.

Scheme 2

Proposed biosynthesis of 1–9. (A) Spr PKS organization and deduced assembly of 1–9. The arrows depict the sequential synthesis of intermediates leading to the mature products 3 and 5–8. The dotted arrows represent module skipping movements leading to 1 and 4. The bold arrow shows the assembly of 9, while the bold dotted arrow leading to 2 involves the skipping of the final module. In both cases, the KR domain in module 7 is inactive. The formation of 1 (B) and 2 (C) involve reactions on premature ACP-bound intermediates.