Table 1.

Proteins involving in maintaining Mn homeostasis

Name and abbreviation	Mn species bound	Function	Reference
Divalent metal transporter (DMT1/SLC11A2)	Mn (II)	Mn uptake	[17]
Transferrin (Tf)	Mn (III)	Mn uptake	[18]
Tf receptor (TfR)	Mn (III)	Mn uptake	[18, 19]
Citrate	Mn (II)	Mn uptake	[20]
ZIP8 (SLC39A8)	Mn (II)	Mn uptake	[21]
ZIP14 (SLC39A14)	Mn (II)	Mn uptake	[22]
Voltage regulated calcium channels	?	Mn uptake	[23]
Ionotropic glutamate receptor—calcium channels	?	Mn uptake	[24]
Store-operated calcium channels	Mn (II)	Mn uptake	[25]
SLC30A10	?	Mn efflux	[26]
Ferroportin (SLC40A1)	Mn (II)	Mn efflux	[27]
Metallothionein	?	storage protein	[28]
Iron regulatory protein-1 (IRP1)	Mn (II)	Mn can replace the 4th Fe in the 4Fe-4S Enzyme action center	[29]
Ceruloplasmin	Mn (II)	Potentially oxidizes Mn (II) to Mn (III)	[30]
Superoxide dismutase	Mn (II)	Oscillates between Mn (II) and Mn (III) species	[31]

Question mark indicates uncertainty