Table 1.
Name and abbreviation | Mn species bound | Function | Reference |
---|---|---|---|
Divalent metal transporter (DMT1/SLC11A2) | Mn (II) | Mn uptake | [17] |
Transferrin (Tf) | Mn (III) | Mn uptake | [18] |
Tf receptor (TfR) | Mn (III) | Mn uptake | [18, 19] |
Citrate | Mn (II) | Mn uptake | [20] |
ZIP8 (SLC39A8) | Mn (II) | Mn uptake | [21] |
ZIP14 (SLC39A14) | Mn (II) | Mn uptake | [22] |
Voltage regulated calcium channels | ? | Mn uptake | [23] |
Ionotropic glutamate receptor—calcium channels | ? | Mn uptake | [24] |
Store-operated calcium channels | Mn (II) | Mn uptake | [25] |
SLC30A10 | ? | Mn efflux | [26] |
Ferroportin (SLC40A1) | Mn (II) | Mn efflux | [27] |
Metallothionein | ? | storage protein | [28] |
Iron regulatory protein-1 (IRP1) | Mn (II) | Mn can replace the 4th Fe in the 4Fe-4S Enzyme action center | [29] |
Ceruloplasmin | Mn (II) | Potentially oxidizes Mn (II) to Mn (III) | [30] |
Superoxide dismutase | Mn (II) | Oscillates between Mn (II) and Mn (III) species | [31] |
Question mark indicates uncertainty