Table 2.
Effect of TCM drugs (100 µg/mL) on activities of ABC transporters, GST, and CYP3A4.
| Plant (family) | Metabolic activity | ||
|---|---|---|---|
| MDR inhibition % |
GST activity (μmol/min/mL) |
CYP3A4 inhibition % |
|
| Areca catechu (Arecaceae) | 1.27 ± 0.13 | 23.46 ± 3.34 | 56.94 ± 4.35 |
| Cassia tora (Fabaceae) | 8.84 ± 0.97 | 31.81 ± 3.54 | 16.38 ± 3.08 |
| Chrysanthemum indicum (Asteraceae) | 9.83 ± 0.89 | 22.86 ± 1.54 | 46.18 ± 4.99 |
| Cymbopogon distans (Poaceae) | 0.28 ± 0.03 | 9.54 ± 1.02 | 2.71 ± 1.53 |
| Cynanchum paniculatum (Apocynaceae) | 19.29 ± 4.32 | 15.70 ± 1.72 | 22.62 ± 3.62 |
| Desmodium styracifolium (Fabaceae) | 171.24 ± 18.54 | 10.93 ± 1.32 | 10.22 ± 3.12 |
| Kadsura longipedunculata (Schisandraceae) | 2.99 ± 0.35 | 10.14 ± 1.39 | 48.30 ± 4.70 |
| Mentha haplocalyx (Lamiaceae) | 8.96 ± 1.00 | 12.92 ± 1.81 | 1.19 ± 0.37 |
| Ophioglossum vulgatum (Ophioglossaceae) | 1.21 ± 0.15 | 13.91 ± 1.96 | 24.91 ± 0.54 |
| Paris polyphylla (Melanthiaceae) | 15.41 ± 2.01 | 18.88 ± 2.11 | 2.92 ± 1.18 |
| Patrinia scabiosaefolia (Valerianaceae) | 6.32 ± 0.82 | 27.43 ± 1.32 | 0.61 ± 0.04 |
| Fallopia japonica (Polygonaceae) | 179.94 ± 18.34 | 14.11 ± 1.23 | 39.81 ± 4.68 |
| Sanguisorba officinalis (Rosaceae) | 35.82 ± 4.65 | 19.88 ± 3.43 | 59.96 ± 3.52 |
| Saposhnikovia divaricata (Apiaceae) | 134.38 ± 15.9 | 7.35 ± 0.67 | 8.21 ± 3.14 |
| Taxillus chinensis (Loranthaceae) | 43.60 ± 5.76 | 9.94 ± 1.9 | 47.41 ± 1.07 |
| Viola yezoensis (Violaceae) | 65.77 ± 6.89 | 15.31 ± 2.85 | 24.97 ± 2.75 |
MDR inhibition calculated as % compared to verapamil as positive control (100%).
Data are means ± S.D. from three independent experiments.