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. Author manuscript; available in PMC: 2015 Aug 22.
Published in final edited form as: Nat Immunol. 2015 Apr 13;16(6):653–662. doi: 10.1038/ni.3148

Figure 6. Aberrant DNA hydroxymethylation of Tet1-deficient stem and progenitor cells.

Figure 6

DNA sequencing data was obtained from purified bone marrow LSK cells of 6 month-old Tet1+/+ and Tet1−/− mice using HELP-GT (n = 2 per genotype) and RRBS (n = 3 per genotype) assays for quantitation of 5hmC and 5mC, respectively. Graphic representation of the differentially methylated genomic regions are displayed as circos plots for a) 5hmC and b) 5mC with respect to their chromosomal location. Bar graphs depict the overall frequency of c) differential hydroxymethylation (%DhMC) compared to d) differential methylation (%DMC) per chromosome and e) genomic location. Differential hyper- and hypo-methylated sites were calculated for CpG sites with methylation difference cutoff >25%, q-value < 0.01.

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