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The flowchart shows the timetable for blood sampling (before and 10 days after HCC induction, posttreatment day 5 and day 15), exosome treatment (after baseline and posttreatment day 10 MR), liver MR and DW imaging (baseline, posttreatment day 10 and day 20), and final killing. Please note that two rats with typical HCC features and four rats with no HCC revealed on baseline MR imaging were killed for histopathological confirmation of MR findings.
