1 |
Normal mucosa |
Normal mucosa |
Normal mucosa |
5–10/50 IEL/epithelial cells |
25% of the villous lamina propria |
2–3 cells per × 40 field |
2 |
Mild villous stunting |
Mild villous epithelial injury |
Mild crypt distension, hyperplasia and distortion |
11–30 IEL/50 epithelial cells. |
25–50% of the villous lamina propria |
5–10 per × 40 field. |
3 |
Moderate villous stunting |
Moderate villous epithelial injury |
Moderate crypt distension, hyperplasia and distortion. |
31–50 IEL/50 epithelial cells may be focally clustered. |
50–75% of the villous lamina propria. |
10–20 per × 40 field. |
4 |
Marked villous stunting |
Marked villous epithelial injury |
Marked crypt distension, hyperplasia and distortion |
51–100 IEL/50 epithelial cells, may be clustered and at all levels of the epithelium |
75–100% of the villous lamina propria. |
> 20 per × 40 field |