Figure 4. rhMG53 exhibits minimal beneficial effects in I-R injury to rat skeletal muscle.
(A) Wet/dry weight in injured GAS muscle nearly doubles compared to uninjured muscle, which is unaffected by rhMG53 treatment. (B) Quantification of the number of muscle fibers that stain positive for EBD confirms the lack of effect of rhMG53 treatment in rats. (C-D) Representative fluorescent images of muscle cross-sections from (C) Control (PBS) and (D) rhMG53 treated rats clearly show similar numbers of EBD positively stained fibers (red) between treatments.