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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Muscle Nerve. 2015 Jun 3;52(5):852–858. doi: 10.1002/mus.24619

Figure 5. Plasma samples derived from rat contain high level of endogenous MG53.

Figure 5

(A) Skeletal muscle samples from mouse and rat showed similar level of endogenous dysferlin, MG53, and caveolin-3. Ponceau S staining was used to show equal loading. Plasma samples from mice and rats (B) or rats and humans (C) were subjected to Western blot analysis. Representative Western blot figure shows that plasma derived from rat contains higher endogenous MG53 than plasma from mouse and human, indicating that mouse might be a better animal model to study MG53-mediated membrane repair. rhMG53 was used as positive control. The results were confirmed by 2 different MG53 antibodies generated from different animal species.