Table 1.
A list of maternal-effect genes in mammalian early embryonic development (M: mouse; B: bovine)
| Genes | Function | Species | References |
|---|---|---|---|
| Ago2 | Degradation of maternal RNA | M | (Lykke-Andersen et al. 2008) |
| Atg5 | Degradation of maternal protein | M | (Tsukamoto et al. 2008) |
|
Basonucli
n |
Transcriptional factor | M | (Ma et al. 2006) |
| Brg1 | Chromatin remodeling; Embryonic genome activation |
M | (Bultman et al. 2006) |
| Brwd1 | Chromatin remodeling | M | (Philipps et al. 2008) |
| Ctcf | Transcriptional factor; Embryonic genome activation |
M | (Wan et al. 2008) |
| Cdh1 | Cell-cell adhesion during compaction | M | (Larue et al. 1994; Riethmacher et al. 1995; De Vries et al. 2004) |
| Dnmt1 | Maintenance of DNA methylation | M, B | (Hirasawa et al. 2008; Golding et al. 2011) |
| Dnmt3a | De novo methyltransferase | M | (Kaneda et al. 2010) |
| Dnmt3l | De novo methyltransferase | M | (Hata et al. 2002) |
| Dicer1 | Degradation of maternal RNA | M | (Murchison et al. 2007) |
| Dppa3 | Maintenance of DNA methylation | M, B | (Nakamura et al. 2007; Bakhtari and Ross 2014) |
| Filia | Component of SCMC, euploidy maintenance | (Zheng and Dean 2009) | |
| Floped | ND | (Li et al. 2008a) | |
| Fmn2 | Meiotic progression | M | (Leader et al. 2002) |
| H1foo | Replacement of protamines | M | (Becker et al. 2005) |
| H3.3 | Reprogramming; decondensation of chromatin | M | (Lin et al. 2013; Inoue and Zhang 2014; Wen et al. 2014) |
| Hira | H3.3 incorporation; rRNA transcription | M | (Inoue and Zhang 2014; Lin et al. 2014) |
| Hsf1 | Redox homeostasis; mitochondria function | M | (Christians et al. 2000; Bierkamp et al. 2010) |
| Kdm1b | Histone H3 lysine 4 (H3K4) demethylase; de novo DNA methylation |
M | (Ciccone et al. 2009) |
| Mater | Component of SCMC | M, B | (Tong et al. 2000) (Pennetier et al. 2006) |
| mHR6A | Degradation of maternal protein; chromatin remodeling |
M | (Roest et al. 2004) |
| Npm2 | Chromatin remodeling | M | (Burns et al. 2003; Inoue et al. 2011) |
| Padi6 | ND | M | (Yurttas et al. 2008) |
| Pdk1 | ND | M | (Zheng et al. 2010) |
| Pms2 | DNA mismatch Repair | M | (Gurtu et al. 2002) |
| Ring1 | Component of Polycomb protein; chromatin remodeling |
M | (Posfai et al. 2012) |
| Rnf2 | Component of Polycomb protein; chromatin remodeling |
M | (Posfai et al. 2012) |
| SEBOX | ND | M | (Kim et al. 2008) |
| Sox2 | Reprogramming gene expression; | M | (Avilion et al. 2003; Pan and Schultz 2011) |
| Tap73 | Spindle assembly; genomic stability | M | (Tomasini et al. 2008) |
| Tcl1 | ND | M | (Narducci et al. 2002) |
| Tet3 | Active DNA demethylation | M,B | (Gu et al. 2011) |
| Tif1a | Chromatin remodeling | M | (Torres-Padilla and Zernicka-Goetz 2006) |
| Tle6 | ND | M | (Yu et al. 2014) |
| Trim28 | Maintenance of DNA methylation | M | (Messerschmidt et al. 2012) |
| UCH1l | Block polyspermy | M | (Sekiguchi et al. 2006) |
| Zar1 | Early embryonic development | M | (Wu et al. 2003) |
| ZFP36l2 | Degradation of maternal factors | M | (Ramos et al. 2004) |
| Zfp57 | Maintenance of DNA methylation | M | (Li et al. 2008b) |
| JY-1 | ND | B | (Bettegowda et al. 2007; Lee et al. 2014a) |
| Follistatin | ND | B | (Patel et al. 2007; Lee et al. 2009) |
| SMAD4 | ND | B | (Lee et al. 2014b) |
| NOBOX | ND | M, B | (Rajkovic et al. 2004; Tripurani et al. 2011) |
| KPNA7 | Nuclear importing | B | (Tejomurtula et al. 2009) |