. Author manuscript; available in PMC: 2016 Oct 1.

Published in final edited form as: J Magn Reson Imaging. 2015 Feb 20;42(4):936–945. doi: 10.1002/jmri.24871

Table 1.

Time schedule of drug (or X-radiation) dosing and imaging of animals.

Tumor type	Groups	Time (days) after therapy initiation

		Day 0	Day 3	Day 7
SCC1	Group 1 (n=4)	DCE-MRI	DCE-MRI	DCE-MRI
	Group 2 (n=5)	Anti-EMMPRIN Ab (0.1 mg) DCE-MRI before dosing	Anti-EMMPRIN Ab (0.1 mg) DCE-MRI before dosing	DCE-MRI
	Group 3 (n=5)	Cisplatin (3 mg/kg) DCE-MRI before dosing	Cisplatin (3 mg/kg) DCE-MRI before dosing	DCE-MRI
	Group 4 (n=5)	X-radiation (2Gy) DCE-MRI before dosing	X-radiation (2Gy) DCE-MRI before dosing	DCE-MRI
	Group 5 (n=5)	Anti-EMMPRIN Ab (0.1 mg) cisplatin (3 mg/kg) DCE-MRI before dosing	Anti-EMMPRIN Ab (0.1 mg) cisplatin (3 mg/kg) DCE-MRI before dosing	DCE-MRI
	Group 6 (n=5)	Anti-EMMPRIN Ab (0.1 mg) X-radiation (2Gy) DCE-MRI before dosing	Anti-EMMPRIN Ab (0.1 mg) X-radiation (2Gy) DCE-MRI before dosing	DCE-MRI

OSC19	Group 7 (n=5)	DCE-MRI	DCE-MRI	DCE-MRI
	Group 8 (n=4)	Anti-EMMPRIN Ab (0.1 mg) DCE-MRI before dosing	Anti-EMMPRIN Ab (0.1 mg) DCE-MRI before dosing	DCE-MRI
	Group 9 (n=4)	Cisplatin (3 mg/kg) DCE-MRI before dosing	Cisplatin (3 mg/kg) DCE-MRI before dosing	DCE-MRI
	Group 10 (n=5)	X-radiation (2Gy) DCE-MRI before dosing	X-radiation (2Gy) DCE-MRI before dosing	DCE-MRI
	Group 11 (n=4)	Anti-EMMPRIN Ab (0.1 mg) cisplatin (3 mg/kg) DCE-MRI before dosing	Anti-EMMPRIN Ab (0.1 mg) cisplatin (3 mg/kg) DCE-MRI before dosing	DCE-MRI
	Group 12 (n=4)	Anti-EMMPRIN Ab (0.1 mg) X-radiation (2Gy) DCE-MRI before dosing	Anti-EMMPRIN Ab (0.1 mg) X-radiation (2Gy) DCE-MRI before dosing	DCE-MRI