Table 1.

Comparative analysis of the TPMT allele frequencies between patients and healthy individuals and by ethnicity.

		ALL cases		Total N=270	Healthy subjects		Total N=177*
		Admixed n= 176	Indigenous n= 84		Admixed n= 88	Indigenous n= 87
Sex , (%)
		59.7	53.6	57.3	22.7	37.9	31.1
Male		40.3	46.4	42.2	77.3	62.1	58.9
Female
Genotypes, (%)
TPMT*1/ TPMT *2		1.1	0	0.7	3.4	0	1.7
TPMT*1/ TPMT *3A		7.5	7.1	7.4	11.4	9.2	10.2
TPMT*3A/ TPMT *3A		0	0	0	0	1.1	0.56
TPMT*1/ TPMT *3B		0	1.2	0.3	0	0	0
TPMT*1/ TPMT *3C		2.1	0	1.5	2.3	0	1.1
Total		10.7	8.3	10.0	16.9	10.3	13.6
P value		0.67			0.41
Allele frequency, (%)
TPMT *2		0.55	0	0.035	1.7	0	0.8
TPMT *3A		3.75	3.6	3.7	5.7	5.7	5.7
TPMT *3B		0	0	0.015	0	0	0
TPMT *3C		1.05	0.6	0.75	1.1	0	0.6
Total		5.4	4.2	5.0	8.5	5.7	7.1
P value		0.67			0.41